As a young pharmacist, I remember the popularity of codeine containing products--Tylenol® With Codeine, Empirin® with Codeine, and many formulations of cough syrups with codeine. But as the years have gone by, the rationale for using these products has fallen by the wayside. First of all, codeine in and of itself is a prodrug. It does not have any pharmacological effect until it is converted by bodily enzymes into morphine, its active form. Due to genetic variability some people do not possess the enzyme that is responsible for this conversion. When these persons are ordered codeine containing products for pain, or for cough, it does not provide analgesia or cough suppression. Conversely, there are also " ultra-rapid metabolizers " of codeine--in this group, codeine is very quickly converted to morphine, so quickly in fact, that the effect can result in toxicity. Since the medical field does not genetically test people routinely to see who can or can't met...
This blog is for chronic pain sufferers and their families. My intent is to help everyone who is affected on some level by chronic pain. I research and present news and ideas to help improve quality of life and minimize suffering and downtime!