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Disruption Of Brain Signals May Play A Role in Fibromyalgia Pain

The term 'hyperalgesia" comes from the Greek language. It is defined as "an increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves."  





  .........New research findings published in Arthritis & Rheumatism suggest that a disruption in brain signals for reward and punishment...contributing to hyperalgesia in patients with fibromyalgia. 


"In patients with fibromyalgia there is an alteration in the central nervous system pain processingand a poor response to topical pain treatments, trigger point injections and opioids," said lead author Dr.Marco Loggia from Massachusetts General Hospital and Harvard Medical School in Boston. "Our study examines the disruption of brain function involved in the individual experience of pain anticipation and pain relief."

This study consisted of 45 subjects: 31 of these had fibromyalgia, while the other 14 were identified as healthy. All subjects were subject to cuff pressure on the leg while an MRI was being performed. Dr. Loggia concludes, "Our findings suggest that fibromyalgia patients exhibit altered brain responses to punishing and rewarding events, such as expectancy of pain and relief of pain. These observations may contribute to explain the heightened sensitivity to pain, as well as the lack of effectiveness of pain medications such as opioids, observed in these patients. Future studies should further investigate the neurochemical basis underlying these dysfunctions."

So while, the jury is still out...it is good to know that the mystery of fibromyalgia is being studied extensively.  I hope for all of you in the storm of fibromyalgia...that the rainbow is soon at hand!

Source: Medical News Today, Wikipedia

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